Borussia Dortmund midfielder Jude Bellingham has been called up to the England senior men's squad following the withdrawals of James Ward-Prowse and Trent Alexander-Arnold through injury.
Bellingham was originally called up to the Under-21 squad but will now join the senior squad where he will be in line for his first cap with matches against Republic of Ireland and Belgium.
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The 17-year-old joined Dortmund from Birmingham this summer, despite interest from Manchester United, and has so far made 11 appearances for the German side, scoring in the 5-0 win over Duisburg in the DFB Pokal .
He was billed as a late substitute in the Der Klassiker against Bayern Munich on Saturday and came close to scoring a late tying goal as Dortmund lost 3-2.
Manchester City midfielder Phil Foden has also been recalled for the first time since September after being dismissed from the camp in disgrace alongside United's Mason Greenwood.
Foden and Greenwood broke coronavirus protocols by inviting two Icelandic women to the England team hotel in Reykjavik.
Both players were left out last month but although Foden was included, Greenwood was not following conversations between Southgate and United boss Ole Gunnar Solskjaer.
Goalkeepers : Jordan Pickford (Everton), Nick Pope (Burnley), Dean Henderson (Manchester United)
Defenders : Ben Chilwell (Chelsea), Conor Coady (Wolverhampton Wanderers), Eric Dier (Tottenham Hotspur), Joe Gomez (Liverpool), Reece James (Chelsea) Michael Keane (Everton), Harry Maguire (Manchester United), Ainsley Maitland-Niles (Arsenal), Tyrone Mings (Aston Villa), Bukayo Saka (Arsenal), Kieran Trippier (Atletico Madrid), Kyle Walker (Manchester City)
Midfielders : Jude Bellingham, (Borussia Dortmund), Phil Foden (Manchester City) Jordan Henderson (Liverpool), Jack Grealish (Aston Villa), Mason Mount (Chelsea), Declan Rice (West Ham), Harry Winks (Tottenham)
Forwards : Tammy Abraham (Chelsea), Dominic Calvert-Lewin (Everton), Harry Kane (Tottenham), Marcus Rashford (Manchester United), Jadon Sancho (Borussia Dortmund), Raheem Sterling (Manchester City)